Do you mean demonically possessed sorority girls? Or maybe sorority girls who are being genetically regressed into velociraptors? Or maybe, worst of all, plain old sorority girls?
Last night I jotted down the bones of a "Fratboys vs. Hot Asian Chicks" game (That will tie back into the research I did for the Chinese fantasy game that didn't go off at Origins in '07. I will get my money's worth out of those books, so help me Eris!)
Actually, at one point we were thinking about doing Fratboys as 2-in-1 type book. One side would be Fratboys vs., but if you flipped it over the other side would be Cheerleaders vs. (the middle pages would of course explain how to do Fratboys vs. Cheerleaders). We never figured out a Cheerleaders setup that really worked--the best we could come up with was a DEBS type "Cheerleader IMF team" kind of thing (nice concept, but doesn't really fit in with Fratboys)--so we dropped the idea (for now...).